Jorge Abreu · Peptide NotesThe R3TA Benefits Guide
Triple receptor, GIP, GLP-1, and glucagon. Here is what the human trials actually reported, beyond the number on the scale, plus the honest answer on what happens when it stops.
4 pages · Phase 3 data + off-treatment research · PDF, instant
What's inside
Four sections, what was observed, in whom, and what still needs proving.
01
Weight, appetite + energy
19.0% to 28.3% mean loss at 80 weeks across dose groups, up to 30.3% in a severe obesity extension at 104 weeks. What's driving satiety, and what's still unquantified about energy expenditure.
02
Body fat + metabolic health
Up to 9.5 inches off the waist, A1C down up to 2.0 points in type 2 diabetes, triglycerides down 41%, systolic blood pressure down up to 12.3 mmHg.
03
Liver, sleep + joint outcomes
Liver fat down 81 to 82% in a small substudy, sleep apnea events down up to 60.6%, knee osteoarthritis pain down up to 73.1%. What's a direct effect and what's likely downstream of weight loss.
04
What happens when it stops
Direct off-treatment data is still pending, TRIUMPH-6 completes in 2028. What related tirzepatide and semaglutide withdrawal trials show, and the six part maintenance checklist to plan before the first dose.
There are no self administered doses anywhere in this guide, and that's deliberate.
This is trial data, group averages from specific study populations, not a protocol. What transfers is the mechanism, the evidence quality, and the honest limits, including the fact that long term cardiovascular, kidney, and muscle outcomes are still under study.
Instant PDF download. No cost. Instant access.
Peptide Talk, the community I run
The guide answers the first questions, what the trials actually showed and what they didn't. The ones after that, how to read a study, how to vet a vendor, what the research says about your specific goal, are easier with other people in the room.
- Six courses: foundations, handling and the math, compound library, by goal, vendor and COA vetting, what not to do
- Vendor and COA vetting from someone who sits on the supply side and will tell you how the lying is done
- Research breakdowns in plain English, no hype, no gurus, no sourcing requests
- Members only feed and live Q and A
$19 a month, founding rate locked for life for the first 50 members. Free trial, cancel anytime. Research use only, no medical advice and no protocols.
Here's the R3TA guide
It's also on its way to your inbox. If it isn't there in a few minutes, check spam and drag it to your primary tab so the rest of the series lands.
Download the PDFRead page 3 first if you're worried about the "what happens after" question, most people are.
Want the rest of it? I run Peptide Talk, a private community for people who want the vetting, the research and the handling done right. $19 a month, free trial.