Growth hormone research

CJC-1295 (No DAC)
research guide

CJC-1295 without DAC, also called Modified GRF (1-29), is a short-acting analog of the first 29 amino acids of growth hormone releasing hormone, chemically modified for stability but without the drug affinity complex that extends CJC-1295 with DAC's duration of action. In Europe PMC literature searches conducted for this page, no dedicated human clinical trial of the no-DAC form specifically was located; the related DAC-conjugated molecule does have published human pharmacology data [1]. No validated human protocol for the no-DAC form was found in the sources reviewed.

Limited direct evidenceEditorial review: September 13, 2026

Direct evidence does not establish a personal use protocol. Literature summary, not clinical peer review.

Looking for the product? Reign listings and business disclosure ↓

Jorge Abreu is not a doctor. This is an educational research summary, not a prescription or a personal dosing plan. Study results do not establish that a supplier product is safe or effective for people. Consult a licensed clinician about medical decisions.

01 · Start with identity

What is CJC-1295 (No DAC)?

CJC-1295 No DAC (Modified GRF 1-29) is chemically distinct from CJC-1295 with DAC in that it lacks the affinity-complex modification, which is reported elsewhere in the pharmacology literature to be the feature responsible for extending duration of action; without it, the peptide is expected to behave more like a short-acting GHRH fragment. Reign Peptide's product is a research-chemical vial of this shorter sequence, not the DAC-conjugated molecule and not a pharmaceutical product.

Also searched as: Modified GRF (1-29), Mod GRF 1-29, tetrasubstituted GHRH(1-29) analog

02 · Read the evidence

What the studies reported

01

Related DAC-conjugated compound has human data

The chemically related, affinity-complex-modified version of this molecule, CJC-1295 with DAC, was studied in randomized, placebo-controlled human trials that reported growth hormone elevation lasting 6 days or more and IGF-1 elevation lasting 9 to 11 days after a single dose; this data describes the DAC-conjugated form's hormone response duration and does not establish evidence for the no-DAC fragment discussed on this page. [1]

02

Structural distinction drives the evidence gap

Because the affinity-complex modification present in CJC-1295 with DAC is reported in the pharmacology literature as the feature extending its duration of action, the no-DAC fragment discussed on this page is expected to be shorter-acting; this expectation is based on the structural difference described for the DAC-conjugated form, not on a direct study of the no-DAC fragment itself. [1]

03 · Numbers in context

What does dosing evidence actually support?

No peer-reviewed human trial dosing data specific to CJC-1295 without DAC was located in the Europe PMC search conducted for this page. The only human pharmacology data identified in this research applies to the structurally related, drug-affinity-complex-modified version (CJC-1295 with DAC), which is a different molecule with a different duration of action, so it cannot be used to describe a dosing schedule for the no-DAC form.

A study dose is not a personal dose. Population, route, formulation and supervision are part of the result. Online community schedules are not treated here as established clinical protocols.

04 · Safety and limits

What not to overlook

  • No validated human clinical trial for CJC-1295 without DAC specifically was found in the sources reviewed for this page.
  • This peptide is chemically distinct from CJC-1295 with DAC; data on one should not be assumed to apply to the other.
  • No FDA-approved indication exists for either form.
  • Research-chemical vials have no independent identity or purity confirmation beyond the seller's stated specification.

05 · Product distinctions

Names are not interchangeable

Reign Peptide sells CJC-1295 (No DAC) as a lyophilized powder vial labeled for laboratory research use, chemically shorter than and distinct from the CJC-1295 with DAC product also sold by the same supplier. No approved pharmaceutical formulation of the no-DAC form exists for comparison.

06 · Handling and storage

Follow validated product instructions

A single water volume, refrigerator temperature or expiry window cannot be assumed for every compound and formulation. Use the exact manufacturer documentation and a validated laboratory procedure. If stability, solvent compatibility or microbiological quality is not documented, those properties remain unverified.

Refrigeration, clear appearance and bacteriostatic water do not make an unverified research product suitable for injection. This guide does not provide a mixing or administration procedure.

The existing concentration calculator checks arithmetic only. It cannot choose a safe dose or establish compatibility, sterility or shelf life.

Reign Peptide · Business disclosure

Research product listings

Jorge Abreu is involved in Reign Peptide. Links to Reign are a business connection, not an independent endorsement. Reign lists these products for laboratory research, not human consumption.

Use the listing to check the labeled identity, amount and available batch documentation. A purity result alone does not verify sterility, clinical suitability or equivalence to a medicine used in a trial.

Names and sizes are product labels, not dosing recommendations. Confirm current details with the seller.

Supplies and accessories

Compare the actual specifications

Jorge's supply directory includes syringes, alcohol pads, storage cases, travel refrigeration and electrolytes, with separate links for the two travel refrigeration options. Accessory availability is not a recommendation to administer a research compound.

Affiliate disclosure: As an Amazon Associate I earn from qualifying purchases.

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Alcohol pads

MED PRIDE, 70% isopropyl, 200 count per listing. An alcohol pad does not establish sterility of a research product.

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Peptide fridge case

Listing: 63 slots for 3mL bottles, bag only. An organizer is not active refrigeration or a validated storage system.

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Peptide travel case

Medineed travel case with temperature display and two ice packs per listing. Check dimensions and transport requirements.

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Questions still worth asking

What remains unresolved?

  • Has any peer-reviewed human pharmacokinetic study of CJC-1295 without the DAC modification been conducted and published?
  • How does the duration of GH stimulation from the no-DAC fragment compare directly to the DAC-conjugated form in a head-to-head study?

Check the source

References and evidence scope

  1. Human trial · 2006Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults ↗

These are the sources reviewed for this page, not an exhaustive systematic review. Related compound research is identified as such. Product links are not scientific references.

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