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Selank
research guide
Selank is a synthetic heptapeptide analogue of tuftsin, studied in Russia primarily as an anxiolytic. An older comparative clinical study reported anxiolytic effects similar to a benzodiazepine comparator in patients with generalized anxiety disorder and neurasthenia. More recent human work has examined its effects on brain functional connectivity, while animal studies describe effects on stress and withdrawal-related behavior. Independent replication outside this research tradition is limited in the sources reviewed.
Evidence depends on population and formulation. Literature summary, not clinical peer review.
Looking for the product? Reign listings and business disclosure ↓
Jorge Abreu is not a doctor. This is an educational research summary, not a prescription or a personal dosing plan. Study results do not establish that a supplier product is safe or effective for people. Consult a licensed clinician about medical decisions.
01 · Start with identity
What is Selank?
Selank is a synthetic peptide analogue of tuftsin, an endogenous immunomodulatory tetrapeptide, extended with additional amino acids; it is not the same molecule as tuftsin itself, and findings for one should not be assumed to apply directly to the other.
Also searched as: Tuftsin analogue peptide
02 · Read the evidence
What the studies reported
01
Comparative clinical study in generalized anxiety disorder
A study of 62 patients with generalized anxiety disorder and neurasthenia compared Selank (30 patients) to medazepam (32 patients) using standardized psychometric scales, reporting similar anxiolytic effects between groups along with additional antiasthenic and psychostimulant effects attributed to Selank, and correlating enkephalin activity with disease measures. [1]
02
Functional connectivity changes seen in healthy adults
A functional connectomic study in 52 healthy participants examined effects of Selank and the related peptide Semax on whole-brain resting-state functional connectivity involving the amygdala and dorsolateral prefrontal cortex, regions relevant to anxiety and executive function. [2]
03
Animal study describes effect on opioid withdrawal
In rats, a single intraperitoneal dose of Selank (0.3 mg/kg) reduced the total index of naloxone-precipitated morphine withdrawal syndrome by 39.6 percent and significantly attenuated convulsive reactions, ptosis, and posture disorders compared to control, though it was slightly less potent than diazepam on some measures. [3]
03 · Numbers in context
What does dosing evidence actually support?
The generalized anxiety disorder study compared Selank against medazepam in a defined patient population using standardized psychiatric rating scales, but this describes that specific study's design and population, not a general dosing recommendation. Rodent studies used doses such as 0.3 mg/kg administered intraperitoneally for specific withdrawal or memory endpoints; these are experimental animal doses and are not directly convertible to a human protocol. No broadly validated human dosing standard beyond the original comparative trial was found in the sources reviewed.
A study dose is not a personal dose. Population, route, formulation and supervision are part of the result. Online community schedules are not treated here as established clinical protocols.
04 · Safety and limits
What not to overlook
- The primary human trial located is decades old, from a specific research tradition, and does not appear to have broad independent replication in the sources reviewed.
- Most mechanistic and behavioral detail comes from rodent studies whose doses do not transfer to human use.
- Selank is an analogue of tuftsin but is not identical to it, and effects should not be assumed interchangeable between the two.
- Functional connectivity changes in healthy volunteers are not the same as demonstrated clinical benefit for an anxiety disorder.
05 · Product distinctions
Names are not interchangeable
Sold as a lyophilized synthetic peptide powder in single-compound vials, as well as in combination nasal spray products with other peptides such as DSIP or Semax. Any combination product's ratio of each peptide is a separate formulation question from the single-compound research literature cited here, and blend-specific human evidence was not identified.
06 · Handling and storage
Follow validated product instructions
A single water volume, refrigerator temperature or expiry window cannot be assumed for every compound and formulation. Use the exact manufacturer documentation and a validated laboratory procedure. If stability, solvent compatibility or microbiological quality is not documented, those properties remain unverified.
Refrigeration, clear appearance and bacteriostatic water do not make an unverified research product suitable for injection. This guide does not provide a mixing or administration procedure.
The existing concentration calculator checks arithmetic only. It cannot choose a safe dose or establish compatibility, sterility or shelf life.
Reign Peptide · Business disclosure
Research product listings
Jorge Abreu is involved in Reign Peptide. Links to Reign are a business connection, not an independent endorsement. Reign lists these products for laboratory research, not human consumption.
Use the listing to check the labeled identity, amount and available batch documentation. A purity result alone does not verify sterility, clinical suitability or equivalence to a medicine used in a trial.
Names and sizes are product labels, not dosing recommendations. Confirm current details with the seller.
Supplies and accessories
Compare the actual specifications
Jorge's supply directory includes syringes, alcohol pads, storage cases, travel refrigeration and electrolytes, with separate links for the two travel refrigeration options. Accessory availability is not a recommendation to administer a research compound.
Affiliate disclosure: As an Amazon Associate I earn from qualifying purchases.
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Peptide fridge case
Listing: 63 slots for 3mL bottles, bag only. An organizer is not active refrigeration or a validated storage system.
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Peptide travel case
Medineed travel case with temperature display and two ice packs per listing. Check dimensions and transport requirements.
View on Amazon ↗Questions still worth asking
What remains unresolved?
- Would a modern, larger randomized controlled trial confirm the anxiolytic effects reported in the original generalized anxiety disorder comparison study?
- Do the functional connectivity changes observed in healthy volunteers correspond to any measurable clinical or cognitive outcome?
Check the source
References and evidence scope
- Human trial · 2008Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia ↗
- Human trial · 2020Functional Connectomic Approach to Studying Selank and Semax Effects ↗
- Animal study · 2022Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats ↗
These are the sources reviewed for this page, not an exhaustive systematic review. Related compound research is identified as such. Product links are not scientific references.
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